Saturday, March 24, 2018

Propolis Helps fight Acne

The Buzzy Ingredient That's Brightening, Acne-Fighting & Youth-Promoting For Sensitive Skin Types

Mind and Body Green, March 19

For all my sensitive skin ladies out there, I present the natural beauty ingredient you need to know about for brightening, acne fighting, and a youthful glow: propolis. This powerful substance, made by honeybees, has been around for centuries yet flown under the radar in modern times, where (often harsh) acids and retinols are touted as the best skin-smoothing ingredients. But if you’re like me and the sheer mention of strong acids and vitamin A derivatives incites the onset of a skin reaction, you’ll be relieved to know about this alternative skin enhancing ingredient.

What is propolis?

I first learned about propolis while interviewing Tanya Hawkes, sustainable beekeeper and founder of organic skin care line Therapi Honey Skincare, who said, "To truly understand what a powerful compound propolis is, you have to look at the plant world. Propolis comes from the giants in the plant kingdom, trees. And trees have evolved to live thousands of years, but in order to do this they have to survive all environmental aggressors: viral, bacterial, pollution, insects, etc. To withstand all of this, trees have created a strong immunity of plant phenol chemicals and bioflavonoids to defend themselves," she said. Bees then piggyback off the trees' powerful immune systems. They harvest the immunity-boosting tree secretions like sap and resin and add enzymes through their body processes, as well as plant and beeswax, to produce an end product that's antiviral, antibacterial, antifungal, anti-inflammatory, and an antioxidant. "The end result is propolis,” she explained.

Wow. Hawkes continued to explain that bees mainly line their hives with propolis as an external immune system but that it can be used in many other ways. For instance, if a mouse were to get inside the hive, which happens with relative frequency, the bees can sting the mouse to death, neutralizing the intruder. But since it’s too large to carry out of the hive, and a decaying rodent would unquestionably bring disease and bacteria, the bees mummify the mouse with propolis, protecting themselves completely from the decaying animal.

Propolis in skin care.

This powerful natural ingredient has become a staple in the natural world. As you might imagine, it can help reduce pigmentation and inflammatory redness, boost collagen, and offer antioxidant protection from environmental aggressors like pollution, sunlight, and radiation.

Personally, I’ve found when using propolis products, my skin appears brighter, and my inflammatory red acne marks fade more quickly. But what I love the most about this ingredient is its ability to produce powerful results gently. Instead of exfoliating my skin with harsh acids to reveal brighter, more youthful skin, propolis allows me to achieve these ends without stripping the skin.

Therapi Honey Skincare’s Propolis + Ultra Radiance Cream is one of my favorite propolis skin care products. I call this cream the "natural alternative to La Mer." It’s made with organic ingredients, including powerful propolis, and offers the perfect blend of water, oil, and waxes to keep my dry, dehydrated skin plump and nourished.

Farmacy’s Honey Potion Renewing Antioxidant Mask is another great option for sensitive skin in need of soothing and revitalizing. The creamy, warming mask contains potent propolis along with another powerful healing substance created by bees: royal jelly, a glandular secretion rich in antioxidants and fatty acids "nurse bees" feed to a larva when they want to turn it into a queen bee.

If I’m dealing with a skin reaction, which undoubtedly happens as a sensitive-skinned beauty blogger (aka guinea pig), in the past I’ve always opted for soothing Manuka honey masks, but recently I’ve discovered and been loving Beekeeper’s Naturals Bee Powdered to quell any irritations. Bee Powered is a potent blend of raw honey, propolis, royal jelly, and bee pollen that makes for a great mask alone or mixed with a spoonful of clay power, like S. W. Basics Hibiscus Mask, for gentle detoxing...

Friday, March 23, 2018

Propolis and Sahara Honeys Prevent Biofilm Formation on Urinary Catheters

Propolis-Sahara honeys preparation exhibits antibacterial and anti-biofilm activity against bacterial biofilms formed on urinary catheters

Asian Pacific Journal of Tropical Disease
Volume 6, Issue 11, November 2016, Pages 873-877


To evaluate the antibacterial effect of Sahara honeys (SHs) against bacterial biofilms formed on urinary catheters in combination with propolis-Sahara honeys (P-SHs).


Three clinical isolates were subjected to biofilm detection methods. The antibacterial and anti-biofilm activity for SHs and P-SHs were determined using agar well diffusion and the percentage of biofilm inhibition (PBI) methods.


The PBI for Gram-positive bacteria [Staphylococcus aureus (S. aureus)] was in the range of 0%–20%, while PBI for Gram-negative bacteria [Pseudomonas aeruginosa and Escherichia coli (E. coli)] were in range of 17%–57% and 16%–65%, respectively. The highest PBI (65%) was produced by SH2 only on E. coli. In agar well diffusion assay, zones of inhibition ranged from 11–20 mm (S. aureus), 9–19 mm (Pseudomonas aeruginosa) and 11–19 mm (E. coli). The highest inhibition (20 mm) was produced by SH1 only on S. aureus. In addition, the treatment of SHs and P-SHs catheters with a polymicrobial biofilms reduced biofilm formation after 48 h exposure period.


SHs and P-SHs applied as a natural agent can be used as a prophylactic agent to prevent the formation of in vitro biofilm.

Thursday, March 22, 2018

Corn Starch Film Containing Propolis Proposed for Wound Dressing, Skin Tissue Engineering

Physicochemical, Antimicrobial and Cytotoxic Characteristics of Corn Starch Film Containing Propolis for Wound Dressing

Journal of Polymers and the Environment pp 1–7

Modern dressings increase the rate of wound healing rather than just covering them. Dressing can protect the injured skin and keep it appropriately moist to speed up the healing process.

In this study, the ethanolic extract of propolis loaded with corn starch was successfully prepared using solvent casting. Characterizations of the samples performed in respect to their mechanical properties were examined by scanning electron microscopy, contact angle, and attenuated total reflectance—fourier transform infrared spectroscopy, as well as antimicrobial capacities.

The MTT assay using fibroblast cells showed the cell viability of corn starch in the ethanolic extract of propolis wound dressing.

The results showed that by increasing the amount of ethanolic propolis extract from 0.25 to 1%, the tensile strength and the Young’s modulus of the samples were decreased, the elongation at the break increased about 15% as compared to the control films, and the contact angle properties were detected by a slightly hydrophobic character of the films in the antibacterial activity against Escherichia coli and Staphylococcus aureus even at low ethanolic extract of propolis concentrations (1%), mainly due to its phenolic compounds.

Therefore, ethanolic extract of propolis loaded with corn starch film will be a potential candidate for wound dressing and skin tissue engineering.

Wednesday, March 21, 2018

Propolis Syrup Delayed Radiation-Induced Esophagitis with Lung Cancer

Efficacy of a Propolis-Based Syrup (FARINGEL) in Preventing Radiation-Induced Esophagitis in Locally Advanced Lung Cancer

Chemotherapy. 2018 Mar 19;63(2):76-82


To evaluate the efficacy of a propolis-based syrup, FARINGEL®, in preventing radiation-induced esophagitis in locally advanced lung cancer patients.


Patients were treated with concurrent chemoradiotherapy (CRT) using involved-field radiotherapy (RT). Every patient received FARINGEL at the beginning of CRT until the first follow-up. The data of the study group were compared with the data of a control group treated without the administration of the syrup.


Forty-five patients were enrolled. Forty-one (91.1%) completed the protocol and were evaluable for esophagitis. Grade ≥2 toxicity occurred in 9/41 patients (22%). No differences in overall toxicity were detected between the study group and the control group (n = 55, 60.9 vs. 54.5%; p = ns). Grade 2-3 esophagitis was lower in the study group in comparison with the control group (22 and 38%, respectively), but statistical significance was not reached (p = 0.09). However, the onset of grade ≥2 esophagitis was delayed in the study group compared to the control group, occurring at higher doses of RT (41.8 vs. 25.4 Gy; p < 0.001). Furthermore, the mean number of interruption days for esophagitis was lower in the study group than in the control group (0.6 ± 2.0 vs. 2.1 ± 3.6; p = 0.025).


FARINGEL was well-tolerated and delayed esophagitis that was induced by CRT for locally advanced lung cancer.

Tuesday, March 20, 2018

Clinical Trial: The Effect of Royal Jelly Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-Fertility Husbands

Brief Summary:

The present Pocock clinical trial study was conducted In the city of Mashhad in Iran between 2015 and 2016. The study inclusion criteria were men with low fertility of sperm motility < 25% and total motility < 50% (asthenozoospermia), no history of endocrine diseases, no diabetes men, no hormonal problems in their wives, and a healthy salpingography in their wives.

The study subjects were voluntarily assigned to royal gel and IUI groups. In royal gel group, 5 grams of royal gel was used after menstruation and every other night before and after intercourse. IUI group received 75 units of FSH from the second day of the cycle. Then vaginal ultrasound was performed from the sixth day of menstrual cycle to determine the right size of follicle. 10000 units of HCG was administered when follicle diameter reached 16mm, and the study subject was prepared for IUI 32-36 hours later. Each subject alternately swapped groups following fertility failure.

Monday, March 19, 2018

Manuka Honey May Help Prevent, Treat Colon Cancer

Inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cells growth. Part 1: Suppression of proliferation, promotion of apoptosis and arrest of cell cycle 

Food & Function, Accepted Manuscript

Numerous investigations have been made on plant phenolic compounds and cancer prevention in recent decades. Manuka honey (MH) represents a good source of phenolic compounds such as luteolin, kaempferol, quercetin, gallic acid and syringic acid.

The aim of this work was to evaluate the chemopreventive effects of MH on human colon cancer HCT-116 and LoVo cells. Both cells were exposed to different concentration of MH (0-20 mg/mL for HCT-116 cells and 0-60 mg/mL for LoVo cells) for 48 h to measure apoptosis and cell cycle arrest as well as apoptosis and cell cycle regulatory gene and protein expression. MH exhibited profound inhibitory effects on cellular growth by reducing the proliferation ability, inducing apoptosis and arresting cell cycle in a dose-dependent manner.

Interestingly, MH treatment in non-malignant cells did not exert any significant toxicity at similar concentration. The apoptosis event was associated with increasing expression of p53, cleaved-PARP and caspase-3, and with the activation of both intrinsic (caspase-9) and extrinsic (caspase-8) apoptotic pathways. MH induced cell cycle arrest at S phase in HCT-116 cells, simultaneously, in LoVo cells, it arrested at G2/M phase through the modulation of cell cycle regulator genes (cyclin D1, cyclin E, CDK2, CDK4, p21, p27 and Rb). The expression of p-Akt was suppressed while the expression of p-p38MAPK, p-Erk1/2 and endoplasmic stress markers (ATF6 and XBP1) was increased for apoptosis induction.

Overall, these findings indicate that MH could be a promising preventive or curative food therapy for colon cancer.

Sunday, March 18, 2018

Propolis Helps Heal Diabetic Foot Ulcers

Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial

Natural Product Research
Formerly Natural Product Letters
Latest Articles

In this randomized controlled trial, diabetic patients with foot ulcers (Wagner grades 1 and 2) were randomly assigned to conventional therapies for diabetic foot ulcer plus topical propolis ointment (5%; twice daily) or conventional therapies alone.

The process of ulcer healing was observed during 4 weeks and compared between the two groups regarding the size, erythema, exudates, white blood cell (WBC) count and erythrocyte sedimentation rate (ESR). The process of ulcer size reduction during the four-week period of study was significantly different between the groups. However, this difference was not significant between the third and fourth weeks. There was no significant difference between two groups regarding erythema and exudate reduction as well as WBC count and ESR.

Administration of topical propolis ointment in addition to the conventional treatments of diabetic foot ulcer could reduce the size of ulcers with Wagner grades 1 and 2.

Saturday, March 17, 2018

NEW PRODUCT: 2:1 Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

NEW PRODUCT: 2:1 Concentrated Bee Propolis in Veggie Capsules, Produced at Organic and Kosher-Certified Facility, Equals 500 mg of Raw Propolis

About the product

• Double-Sealed Bottle to Ensure Freshness and Purity
• 100 Count, Capsule Shell: Vegetable Cellulose
• Bottled in the United States at an NSF, Organic and Kosher Certified-Facility that Adheres to Good Manufacturing Practices (GMP)
• Stringent Quality Control Process Monitors Production from Raw Materials to Finished Product
• Product is Tested and Inspected at Intervals During Manufacture

BUY ApisVita Standardized Bee Propolis

Product description

• Propolis, often called “bee glue,” is a natural resinous compound produced by honey bees from botanical sources and is used to seal openings in the hive and to protect its interior from bacteria and fungi. The word “propolis” is derived from the Greek words “pro” (before) and “polis” (city), meaning “before the city” or “defender of the city.” In this case, the “city” is the hive.

• Propolis contains flavonoids, caffeic acid esters and diterpenic acids, which give it bactericidal, antiviral and antifungal properties.

• Propolisis reputed to have antiseptic, antibacterial, anti-mycotic, astringent, spasmolytic, anti-inflammatory, anaesthetic, antioxidant, anti-tumor, anti-fungal, anti-ulcer, anti-cancer, and immunomodulatory effects.

• Propolis has been used in traditional medicine for millennia. Propolis pellets were even found among the grave goods in Paleolithic and Mesolithic burials of northeastern Italy.

“Throughout their 6,000 year civilization, the Egyptians used propolis medicinally as well as for the mummification of cadavers. The ancient Greeks used propolis to speed up the healing of wounds and Aristotle recommended it for all afflictions of the skin. The Roman legionnaires reportedly carried small amounts of propolis with them into battle, not only to help speed up wound healing but for its analgesic (numbing) properties. The Incas used propolis for infections. During the Boer War, the British used it to keep wounds from becoming infected. Throughout history, propolis has played an important role in veterinary medicine since many of the human uses for propolis are applicable to animals.” (Bee Culture Magazine, 10/21/2016)

Brazilian Red Propolis Shows Antimicrobial, Anti-Inflammatory, Antiparasitic, Antitumor, Antioxidant, Metabolic and Nutraceutical Activities

Biological activities of red propolis: a review

Recent Pat Endocr Metab Immune Drug Discov. 2018 Feb 23

• Background: The red propolis (RdProp) is a resin produced by Apis mellifera bees, which collect the reddish exudate on the surface of its botanic source, the species Dalbergiae castophyllum, popularly known in Brazil as "rabo de bugio". Considered as the 13th type of Brazilian propolis, this resin has been gaining prominence due to its natural composition, rich in bioactive substances not found in other types of propolis.

• Objective: This review aims to address the most important characteristics of PV, its botanical origin, the main constituents, its biological properties and the patents related to this natural product.

• Method: By means of the SciFinder, Google Patents, Patus® and Spacenet, scientific articles and patents involving the term "red propolis" were searched until August 2017

• Results: A number of biological properties, including antimicrobial, anti-inflammatory, antiparasitic, antitumor, antioxidant, metabolic and nutraceutical activities are attributed to RdProp, demonstrating the great potential of its use in the food, pharmaceutical and cosmetics industries.

• Conclusion: The available papers are associated to pharmacological potential of RdProp, but the molecular mechanisms or bioactive compounds responsible for each activity have not yet been fully elucidated.

Friday, March 16, 2018

Royal Jelly May Help Treat Infertility

Protective potential of royal jelly against cadmium-induced infertility in male rats

Andrologia. 2018 Mar 12

This study aimed to investigate the protective potential of Royal jelly (RJ) against cadmium (Cd)-induced testicular dysfunction in rats.

Thirty-five adult male Wistar rats were assigned into five groups. G I; (control) injected intraperitoneally with saline, G II injected intraperitoneally with a single dose of CdCl2 (1 mg/kg BW), G III received RJ (100 mg/kg BW/day) orally, G IV was pre-treated with RJ for 1 week then, treated with CdCl2 , and G V was co-treated with RJ and CdCl2 .

After day 56, serum and tissue samples were collected and analysed. The results showed decreased serum testosterone, luteinising hormone (LH), follicle-stimulating hormone (FSH), superoxide dismutase, glutathione reductase, sperm motility and count while increased malondialdehyde, nitric oxide, tumour necrosis factor-α (TNF-α) and sperm abnormalities, along with a severely damaged seminiferous tubules epithelium with cytoplasmic and nuclear disruptions following Cd toxicity.

Additionally, Cd stimulated testicular mRNA expression of TNF-α while inhibited those of steroidogenic acute regulatory protein, cytochrome P450 cholesterol side chain cleavage enzyme androgen binding protein, FSH-receptor, LH-receptor, androgen receptor, 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, and cytochrome P450 17A1. These negative alterations of cadmium were greatly reduced by RJ treatment.

This study concluded that RJ protects against Cd-induced testicular toxicity.

Thursday, March 15, 2018

Bee Venom May Help Treat Allergies

Inhibitory effects of bee venom on mast cell-mediated allergic inflammatory responses

Int J Mol Med. 2018 Mar 12

Although bee venom (BV) is a toxin that causes bee stings to be painful, it has been widely used clinically for the treatment of certain immune‑associated diseases. BV has been used traditionally for the treatment of chronic inflammatory diseases.

In this regard, the present study analyzed the effect of BV on the regulation of inflammatory mediator production by mast cells and their allergic inflammatory responses in an animal model. HMC‑1 cells were treated with BV prior to stimulation with phorbol‑12‑myristate 13‑acetate plus calcium ionophore A23187 (PMACI). The production of allergy‑associated pro‑inflammatory mediators was examined, and the underlying mechanisms were investigated. Furthermore, to investigate whether BV exhibits anti‑inflammatory effects associated with anti‑allergic effects in vivo, a compound 48/80‑induced anaphylaxis model was used. BV inhibited histamine release, mRNA expression and production of cytokines in the PMACI‑stimulated HMC‑1 cells. Furthermore, the inhibitory effects of BV on mitogen‑activated protein kinase (MAPK), MAPK kinase, signal transducer and activator of transcription 3 (STAT3) and Akt were demonstrated.

The present study also investigated the ability of BV to inhibit compound 48/80‑induced systemic anaphylaxis in vivo. BV protected the mice against compound 48/80‑induced anaphylactic‑associated mortality. Furthermore, BV suppressed the mRNA expression levels of pro‑inflammatory cytokines, and suppressed the activation of MAPK and STAT3 in this model.

These results provide novel insights into the possible role of BV as a modulator for mast cell‑mediated allergic inflammatory disorders.

Wednesday, March 14, 2018

Bee Venom May Help Treat Chronic Sinusitis

Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model

Mol Med Rep. 2018 Mar 9

Bee venom (BV) has long been used as anti-inflammatory agent in traditional oriental medicine; however, the effect of BV on chronic rhinosinusitis (CRS) is not commonly studied.

The aim of the present study was to determine the anti-inflammatory effect of BV on an allergic CRS mouse model. An allergic CRS mouse model was established following the administration of ovalbumin with Staphylococcus aureus enterotoxin B (SEB) into the nose. A total of 0.5 or 5 ng/ml of BV were intranasally applied 3 times a week for 8 weeks. Histopathological alterations were observed using hematoxylin and eosin, and Periodic acid Schiff staining.

The levels of inflammatory cell infiltration, interleukin (IL)‑4, IL‑10 and interferon (INF)‑γ in nasal lavage fluid (NLF) were measured. Nuclear factor (NF)‑κB and activator protein (AP)‑1 expressions were also determined by immunohistochemical staining. The group treated with BV had significantly decreased inflammatory cell infiltration and PAS‑positive cells. The levels of INF‑γ, and neutrophil and eosinophil counts in NLF were significantly decreased, and the SEB‑induced NF‑κB and AP‑1 expressions in mouse nasal mucosa were significantly suppressed by 0.5 and 5 ng/ml BV.

Thus, BV exerted significant anti‑inflammatory effects in an allergic CRS mouse model and may have potential value for the treatment of CRS.

Tuesday, March 13, 2018

Addition of Propolis Has Anti-Listerial Effect in Milk

Inhibitory activity of propolis against Listeria monocytogenes in milk stored under refrigeration

Food Microbiol. 2018 Aug;73:168-176

Propolis is a natural bee-product with documented antimicrobial properties in vitro. The objective of this study was to develop a protocol for adding propolis into milk and to determine whether the addition of propolis can confer anti-listerial activity during the storage of milk under optimal or improper refrigeration conditions.

Upon dissolving propolis ethanolic extract (PEE) into glycerol, the PEE-glycerol mixture contained no visible insoluble particles and could be dispersed evenly into milk, without leaving any insoluble material. PEE, with or without glycerol, was added into extended shelf-life milk, artificially contaminated with Listeria monocytogenes.

The addition of PEE dissolved into glycerol resulted in a pronounced and dose-dependent anti-listerial effect in milk stored at 4 °C, with the higher concentration tested (4 mg of dry PEE per mL of milk) resulting in complete inhibition of L. monocytogenes growth throughout 30 days of storage. The combination of PEE with glycerol was also effective in significantly reducing the growth rate of the pathogen in milk stored under improper refrigeration (10 °C).

Based on a patented PEE-deodorization protocol, the addition of deodorized PEE into milk resulted in a product with average consumer acceptability. However, the PEE deodorization process resulted in reduction or even complete removal of propolis constituents with known antibacterial activity, with a concomitant significant reduction in its anti-listerial effect.

Nonetheless, the data presented in this manuscript highlight the strong anti-listerial potential of propolis in milk and suggest that, upon further research on its deodorization and standardization, there may be room for the application of propolis as a natural preservative in dairy beverages.

Monday, March 12, 2018

Brazilian Green Propolis May Help Treat Cancer

Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action

Int J Oncol. 2018 Mar;52(3):925-932

Propolis, a resinous substance collected by honeybees by mixing their saliva with plant sources, including tree bark and leaves and then mixed with secreted beeswax, possesses a variety of bioactivities.

Whereas caffeic acid phenethyl ester (CAPE) has been recognized as a major bioactive ingredient in New Zealand propolis, Brazilian green propolis, on the other hand, possesses artepillin C (ARC). In this study, we report that, similar to CAPE, ARC docks into and abrogates mortalin-p53 complexes, causing the activation of p53 and the growth arrest of cancer cells.

Cell viability assays using ARC and green propolis-supercritical extract (GPSE) revealed higher cytotoxicity in the latter, supported by nuclear translocation and the activation of p53.

Furthermore, in vivo tumor suppression assays using nude mice, we found that GPSE and its conjugate with γ cyclodextrin (γCD) possessed more potent anticancer activity than purified ARC. GPSE‑γCD may thus be recommended as a natural, effective and economic anticancer amalgam.

Sunday, March 11, 2018

Propolis May Help Treat Celiac Disease

Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway

Inflammopharmacology. 2018 Mar 7

Celiac Disease (CeD) is a chronic immune-mediated enteropathy, in which dietary gluten induces an inflammatory reaction, predominantly in the duodenum. Propolis is a resinous hive product, collected by honeybees from various plant sources.

Propolis is well-known for its anti-inflammatory, anti-oxidant and immunomodulatory effects, due to its major compounds, polyphenols and flavonoids. The aim of our study was to assess the ex vivo effect of ethanolic extract of propolis (EEP) upon the activity and expression of iNOS, along with IFN-γ and IL-10 production in Algerian Celiac patients. In this context, PBMCs isolated from peripheral blood of Celiac patients and healthy controls were cultured with different concentrations of EEP. NO production was measured using the Griess method, whereas quantitation of IFN-γ and IL-10 levels was performed by ELISA. Inducible nitric oxide synthase (iNOS) expression, NFκB and pSTAT-3 activity were analyzed by immunofluorescence assay.

Our results showed that PBMCs from Celiac patients produced high levels of NO and IFN-γ compared with healthy controls (HC). Interestingly, EEP reduced significantly, NO and IFN-γ levels and significantly increased IL-10 levels at a concentration of 50 µg/mL. Importantly, EEP downmodulated the iNOS expression as well as the activity of NFκB and pSTAT-3 transcription factors.

Altogether, our results highlight the immunomodulatory effect of propolis on NO pathway and on pro-inflammatory cytokines. Therefore, we suggest that propolis may constitute a potential candidate to modulate inflammation during Celiac Disease and has a potential therapeutic value.